Manager, Product Lifecycle Management (LCM) Execution

Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We discover, develop, manufacture and deliver innovative medicines to help millions of patients. Amgen helped establish the biotechnology industry more than 40 years ago and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today.

• Lead, coach and develop a high-performing team of approximately 7–8 Senior Associates responsible for Lifecycle Management execution.
• Establish clear objectives, priorities and performance expectations aligned with Product Management and Supply Chain objectives.
• Foster a culture of accountability, collaboration, continuous improvement and customer focus.
• Develop organizational capability through coaching, mentoring, talent development and succession planning.
• Manage resource allocation, workload balancing and portfolio prioritization to ensure effective execution and business continuity.
• Drive employee engagement and create an environment that promotes learning, innovation and operational excellence.

• Oversee the execution of post-approval Lifecycle Management activities across Amgen's commercial portfolio.
• Ensure successful delivery of CMC variations, labeling changes, SKU rationalizations, product discontinuations and other lifecycle initiatives.
• Translate Product Lifecycle Team (PLT) decisions into executable work plans and coordinate implementation across the Lifecycle Management Execution team.
• Ensure integrated project plans are developed, maintained and executed in alignment with agreed timelines and business priorities.
• Monitor portfolio progress, proactively manage project risks and remove execution barriers.
• Ensure consistent application of project management methodologies, governance and best practices across all lifecycle activities.

• Lead the execution of Change Controls supporting Lifecycle Management activities in accordance with GMP, regulatory requirements and Amgen procedures.
• Ensure Change Controls are planned, coordinated, implemented and closed within agreed timelines.
• Coordinate execution across Manufacturing, Quality, Regulatory Affairs, Supply Chain, Planning and other impacted functions.
• Monitor Change Control performance, compliance and milestone achievement.
• Escalate critical risks, issues and delays, driving timely resolution with key stakeholders.
• Ensure accurate project documentation, execution records and audit readiness.

• Partner with Product Lifecycle Teams (PLTs), Regional Operations Leads, Manufacturing Sites, Regulatory Affairs, Quality Assurance, Artwork & Labeling, Planning, Procurement and Commercial organizations to ensure successful implementation of lifecycle initiatives.
• Facilitate cross-functional meetings to monitor execution progress, resolve issues and maintain alignment.
• Provide regular portfolio updates, performance metrics and risk assessments to Product Management leadership.
• Support implementation planning for complex lifecycle initiatives requiring coordination across multiple functions and geographies.
• Build strong collaborative relationships across Regional and Site Operations to ensure successful execution.

• Establish and monitor KPIs for Lifecycle Management execution, ensuring delivery against business objectives.
• Drive continuous improvement of project management practices, governance and execution processes.
• Standardize tools, templates, methodologies and ways of working across the Lifecycle Management Execution team.
• Identify opportunities to improve efficiency through process simplification, automation and digital enablement.
• Promote knowledge sharing and implementation of best practices across the Product Management organization.
• Support capability development initiatives that improve execution quality, predictability and operational performance.

• Bachelor's degree in Supply Chain Management, Engineering, Life Sciences, Business or a related discipline.
• 8+ years of experience in pharmaceutical Supply Chain, Manufacturing, Product Lifecycle Management, Regulatory Affairs or Project Management.
• Previous experience leading project managers or operational teams in a matrixed environment.
• Demonstrated experience managing complex portfolios and multiple concurrent projects.
• Strong knowledge of post-approval Lifecycle Management processes, CMC variations, labeling changes and Change Control execution.
• Experience working in GMP-regulated pharmaceutical manufacturing environments.
• Strong project management, stakeholder management and organizational leadership skills.
• Excellent analytical, communication and problem-solving capabilities.

• Experience working within Product Lifecycle Teams (PLTs).
• Knowledge of pharmaceutical commercialization processes.
• Experience with SAP, project portfolio management tools and Smartsheet/MS Project.
• Lean, Six Sigma or Operational Excellence experience.
• Project Management certification (PMP, PRINCE2 or equivalent).

• Master’s degree in Supply Chain Management, Engineering, Business, or related field.
• PMP, PRINCE2 or equivalent Project Management certification.
• Lean Six Sigma Green Belt or equivalent Operational Excellence certification.

• Strong verbal and written communication skills.
• Proven people leadership and coaching capabilities.
• Excellent stakeholder management and influencing skills.
• Strong planning, prioritization and organizational skills.
• Ability to lead multiple priorities in a fast-paced environment.
• High degree of initiative, accountability and ownership.
• Strong analytical and decision-making capabilities.
• Ability to navigate ambiguity and lead through change.
• Collaborative leadership style with a continuous improvement mindset.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.