Principal Biologist

AQEMIA is a drug invention company dedicated to creating entirely new medicines to address major unmet medical needs. At the core of our mission is QEMI, our proprietary molecule-invention platform, which uniquely combines cutting-edge science with advanced technology. Powered by physics-based modeling, statistical mechanics, and generative AI, QEMI allows our teams to design novel drug candidates from first principles.

 

What makes AQEMIA different is our commitment to true innovation: our research is dedicated to the invention of new molecular entities, not the refinement of existing ones. We focus on inventing never-before-seen molecules, without relying on experimental data, and advancing them into a growing pipeline of proprietary programs and strategic partnerships with leading pharmaceutical companies.

 

Our most advanced preclinical programs are currently in vivo optimization, targeting diseases still waiting for effective treatments, offering our teams the opportunity to work on science that can make a real difference in people’s lives.

 

For more information, visit AQEMIA.com, our WTTJ Page, and our LinkedIn. 

 

AQEMIA brings together a diverse, multidisciplinary team of 80+ professionals based in Paris and London. Our scientists and engineers, including chemists, physicists, machine learning experts, and software engineers, work side by side to push the boundaries of early-stage drug discovery.

 

This close collaboration across disciplines is central to our approach, enabling us to tackle complex scientific challenges from first principles and translate cutting-edge ideas into novel therapeutic candidates. At AQEMIA, team members are encouraged to contribute their expertise, learn from one another, and play an active role in shaping the future of drug invention.

 

The Drug Discovery Sciences team (~20 people) combines expertise in medicinal chemistry, computational chemistry, biology, and translational science .

Working at the intersection of AI-driven drug design, molecular simulations, and experimental science, the team is responsible for driving scientific excellence across Aqemia’s drug discovery programs and delivering clinical candidates.

They develop and apply innovative methodologies ensuring that scientific insights translate into high-quality therapeutic opportunities.

Partnering closely with Platform, Engineering, and Program teams, they play a critical role in advancing novel small-molecule therapeutics from concept to clinical candidate.

 

Drive the identification, validation, and selection of novel biological targets aligned with clear unmet medical needs

Contribute to early-stage project ideation by providing deep biological insight and a strong understanding of the drug discovery value chain

Guide programs from early discovery into the AQEMIA pipeline, supporting progression toward proof of concept

Design, implement, and maintain screening cascades to enable efficient compound evaluation and decision-making

Partner with project teams to provide biological expertise, identify risks, and support data-driven prioritization

Manage and collaborate with external CROs to define experimental strategies and ensure generation of high-quality, decision-enabling datasets

Foster cross-functional collaboration, integrating biology with chemistry, modeling, and platform teams

PhD in biological sciences (e.g., pharmacology, molecular biology, chemical biology, biochemistry) or equivalent industry experience

Strong experience in small molecule drug discovery, including progression from hit identification to candidate nomination

Significant industry experience (typically ~8+ years) in early-stage drug discovery and project ideation

Demonstrated expertise in oncology and/or immuno-oncology

Solid understanding of experimental biology, with hands-on wet lab experience to effectively guide and challenge external partners

Proven ability to apply rigorous, data-driven thinking in a multidisciplinary environment

Experience working in a Contract Research Organization-based or highly outsourced R&D model

Track record of contributing to innovative drug discovery strategies aligned with business objectives

Experience in project or portfolio management across complex, cross-functional teams

Strong ability to anticipate and mitigate scientific and strategic risks

Familiarity with translational biology and biomarker strategies