Kyverna4d ago

Sr. Clinical Research Scientist

RemoteFull Timesenior

Data ScientistData

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Clinical Development Location: Remote eligible Reports To: Director, Clinical Research Scientist Support the design, development, and execution of clinical stud

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Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company advancing cell therapies for autoimmune diseases. Guided by our core values—Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome—we are building the foundation for the next generation of cell therapy. This is an opportunity to join at a critical stage and directly shape how clinical development is executed as we scale.

Kyverna is seeking a Senior Clinical Research Scientist who thrives in a fast-paced, build-phase environment and is motivated by the opportunity to create, implement, and optimize clinical processes from the ground up. This role will support the design, execution, and analysis of clinical studies in accordance with GCP and regulatory requirements.

This individual will operate with a high degree of ownership and autonomy, partnering cross-functionally with Clinical Operations, Medical, Biometrics, Regulatory, and external partners to drive high-quality study execution. The ideal candidate is a proactive, hands-on, team player with strong analytical skills.

Department: Clinical Development

Location: Remote eligible

Reports To: Director, Clinical Research Scientist

Support the design, development, and execution of clinical studies, with accountability for protocols, clinical documents, and overall study quality in alignment with GCP and regulatory expectations. Including but not limited to:

Performing comprehensive, ongoing review of clinical trial data (e.g., safety, efficacy, adverse events, laboratory data)
Identifying data trends, discrepancies, and potential safety signals; escalating findings appropriately
Generating, tracking, and resolving data queries in collaboration with data management and clinical operations
Ensuring accuracy, completeness, and consistency of clinical data across systems and reports
Participating in study start-up and oversight activities, including vendor management and CRO collaboration
Contribute to site-facing activities, including investigator support, training, and query resolution
Proactively identify risks and implement mitigation strategies, particularly in areas such as enrollment, site performance, and operational execution.
Participate in the development, writing, and review of key clinical and regulatory documents, including protocols, clinical study reports, informed consent forms, safety updates, and submission materials.
Support clinical data review and interpretation, including safety and efficacy data
Maintain deep understanding of program data and evolving clinical insights
Support publication and data dissemination strategies, including development of abstracts, presentations, and manuscripts.

Advanced scientific degree required (PhD, PharmD, MD, or equivalent).

2+ years of experience in clinical research within biotech or pharmaceutical environments, with a strong preference for candidates who have operated in early-stage or build-phase companies.

Demonstrated ability to work independently and collaboratively in ambiguous, fast-moving environments with limited infrastructure

Strong understanding of GCP, clinical trial design, and regulatory requirements, with the ability to balance scientific rigor, compliance, and practical execution.

Experience with electronic data capture (EDC) systems (e.g., Medidata RAVE or similar); prior involvement in data query management and data cleaning activities preferred

Experience with clinical data review, including safety, efficacy, and/or laboratory data, and familiarity with statistical approaches

Hands-on experience with data visualization software (e.g., GraphPad Prism)

Excellent written and verbal communication skills, with the ability to distill complex scientific information and influence cross-functional stakeholders.

High attention to detail and strong organizational skills

Experience in autoimmune disease, immunology, neurology, or hematology is preferred.

Willingness to travel as needed to support clinical sites, investigator meetings, and scientific conferences.