Postdoctoral Fellow-MSH

Roles & Responsibilities:

Position Overview
Icahn School of Medicine at Mount Sinai, NYC is seeking to hire a medicinal chemistry postdoctoral fellow for novel small molecule drug discovery projects in interesting therapeutic areas of unmet medical need including diabetes, orphan disease, neuroscience, IBD and oncology.

The role will require the structure-based drug design and synthesis of novel medicinal compounds for testing in in vitro and in vivo assays that support the basic biology and drug discovery research efforts. PhD in medicinal chemistry or organic synthesis required.

Duties and Responsibilities
Docking and structure-based drug design based on known ligands and X-ray crystallography co-crystal data available from collaborator labs. Preparation, purification and characterization of compounds in chemistry laboratory; documentation of all experiments in electronic lab notebooks (ELN) including written, publication quality, experimental procedures. Operation and maintenance of laboratory instruments - HPLC and LC-MS for example. Safe laboratory habits and experimental practices.

Opportunities for professional development
The position will allow the candidate to develop valuable new skills and experience in early drug discovery and chemical biology in a highly collaborative research environment.
These include:
Collaborate to validate novel biological targets
Chemical biology tool synthesis and development
Structure-based drug design; Schrodinger software suite
High throughput screening hit validation and analysis
Hit and Lead identification
Lead optimization medicinal chemistry and pre-clinical candidate selection
Analysis of in vitro and in vivo activity of compounds (pharmacodynamics)
Chemo and bioinformatics database development and data analysis
Optimize physical-chemical properties of drug molecules
Study Absorption, Distribution, Metabolism and Excretion (ADME) properties
Evaluate drug metabolism and pharmacokinetics (DMPK) in preclinical species
External collaboration and public presentation skills

Requirements:

PhD

.

.