Postdoctoral Fellow-MSH

Roles & Responsibilities:

Dr. Amaia Lujambio´s research group studies mechanisms of liver cancer initiation and liver cancer maintenance. In particular, we are interested in how genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create vulnerabilities that may be targeted therapeutically. Our research interests involve the establishment of precision in vitro and in vivo systems for the study of liver cancer, as well as the rational use of shRNA and CRISPR libraries to identify drug targets for the disease. We utilize sophisticated mouse models of cancer, RNAi technology, valuable human cancer samples, and genetic and immune profiling as key tools. The ultimate goal is to improve our understanding of liver cancer and to identify novel strategies that can be exploited therapeutically to improve healthspan and longevity.

The project aims at understanding the contribution of different genetic alterations to intra-tumor heterogeneity in hepatocellular carcinoma (HCC). The project will involve the use of mouse models of liver cancer, patient tumor samples, and single-cell phenotyping by scRNA-seq, Cytof, and multiplex immunostainings.

We are accepting applications from talented and enthusiastic candidates who are interested in a dynamic, well-supported lab at a top research institution. The successful candidate must have, or be expecting, a Ph.D. in molecular biology, cell biology, or a related topic. Computational skills and mouse experience are a plus. The candidate will be expected to work well in a collaborative environment and to have strong communication skills.

Interested applicants should submit an electronic copy of their CV, the names and contact information of three referents, and a cover letter describing past research experience, research interests, and career goals

Requirements:

PhD

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