Postdoctoral Scholar

The laboratory of Teresa Zimmers is looking for a postdoctoral associate to study molecular mechanisms of pancreatic cancer. The ideal candidate will have experience with murine models of cancer and pre-cancer, bulk/single cell/spatial transcriptomics, immunofluorescence imaging and advanced microscopy including confocal imaging, 2D and 3D cell culture approaches, induced pluripotent stem cells (iPSC) cell culture and organoids, as well as general expertise in most typical molecular biology techniques and cell culture.

 

Studies will use murine models of pancreatic cancer and human biospecimens from patients with and without pancreatic cancer. Techniques used include orthotopic implantation of tumor cells/fragments to the pancreas, 2D/3D/organoid culture, and molecular and cellular interrogation of murine and human biospecimens. Molecular approaches will include RNAseq, single nucleus RNAseq, immunohistochemistry, ELISA, Western blotting, qPCR.

 

The ideal candidate will want to interrogate mechanisms beyond the current focus of the laboratory in order to develop an independent line of investigation. The candidate will plan, execute, analyze, and present experiments and data. The person fulfilling this position will also write manuscripts and proportionately assist with general lab duties including shared responsibilities for equipment, ordering, and mentoring of trainees.

• Carry out research studies in support of the principal investigator’s funded research on cancer cachexia, including designing and performing experiments, collecting data, analyzing data, presenting data, preparing, presenting and publishing results.
• Help mentor trainees and students rotating in the lab.
• Perform a modest share of general lab duties.
• Engage in growth and learning opportunities and discovery studies.
• Other duties as assigned.

• PhD in related field.

• Experience with mouse models of pancreatic cancer and pre-cancer.

• Demonstrated success in studying pancreatic cancer.

• Ability to conduct in vitro and in vivo studies, including 2D, 3D, and organoid cultures.

• Ability to generate organoids from iPSC cells.

• Ability to assess tissue/organoid morphology through advanced imaging and immunofluorescence.

• Ability to conduct and analyze bulk, single cell, and spatial transcriptomics.

• Experience with mouse models.

• Experience in a basic science or translational laboratory and demonstrated success at carrying projects through to publication.

• Ability to design and execute experiments reproducibly.

• Ability to analyze data with rigor.

• Willingness to learn new approaches, techniques.

• Adheres to standards of responsible conduct of research.

Will work collaborative within a laboratory group with hours that might occasionally be irregular to accommodate experimental timelines. Will work in the RLSB at OHSU. Will be able to travel to conferences to present research. Will work with mouse models, mouse tissues, human tissues, and human clinical data. Will work with recombinant DNA, recombinant viruses, genetically modified mice, chemotherapy drugs, other hazardous chemicals and biospecimens.

 

We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.edu