Research Associate II - Senior Research Associate I, Therapeutic Translation

We are seeking a motivated and creative Research Associate to join our Therapeutic Translation Team. In collaboration with members of the Therapeutic Translation, Cellular Models and Automation teams, you will design, validate and execute high-throughput experiments to characterize and optimize therapeutic gene editing proteins. Your work will be foundational for expanding our gene editing toolbox and translating these advances to new therapeutic opportunities.

The ideal candidate will have experience with molecular biology, mammalian cell culture and NGS preparation workflows. This is an excellent opportunity to work cross-functionally with a diverse team of experts across machine learning, protein design, cell biology, gene editing and laboratory automation. 

• →Design, validate and execute end-to-end assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods
• →Maintain organized tracking of physical samples, reagents, consumables, and assay materials to support efficient high-throughput screening operations, including inventory management, sample traceability, procurement coordination
• →Compile and analyze data to inform critical go/no-go decisions, and clearly present conclusions and rationale to stakeholders across the organization
• →Collaborate with interdisciplinary teams to optimize engineered protein candidates for therapeutic applications
• →Stay up to date on the latest developments in gene editing technology

• BS degree in Molecular Biology, Biochemistry, Cell Biology, or a related field with 2 - 4 years of experience or a MS degree within the same fields and 0 - 2 years of experience
• Hands-on experience with molecular biology & cloning workflows
• Hands-on experience with mammalian cell culture & maintenance
• Conceptual understanding of illumina NGS library preparation & QC 

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

• Experience with CRISPR and/or mammalian cell-based gene editing assays
• Experience using Benchling as an electronic lab notebook and LIMS system
• Experience with high throughput and/or pooled screening workflows
• Experience with the design or execution of NGS-based assays and analysis workflows
• Experience analyzing large experimental datasets (i.e. Python, SQL, JMP)
• Understanding of the key concepts and challenges related to the field of genetic medicine, gene editing systems, DNA repair, etc. 

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.