Principal Scientist/Director, Translational Pharmacology

United States·EmeryvilleFull-timelead

OtherPrincipal

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Overview

We are seeking a highly motivated, hands-on Director of Translational Pharmacology to lead and drive preclinical pharmacology efforts across our pipeline.

Technical Tools

data-analysis

We are seeking a highly motivated, hands-on Director of Translational Pharmacology to lead and drive preclinical pharmacology efforts across our pipeline. This individual will play a central, decision-making role in translating innovative science into rigorous, in vivo proof-of-concept and clinically actionable pharmacology strategies.

Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs

Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies

Design and oversee in vivo studies, including selection and development of appropriate animal models

Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making

Translate preclinical findings into clinically relevant hypotheses and development strategies

Collaborate closely with teams to optimize drug candidates and delivery systems

Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)

Build and manage relationships with CROs and external collaborators

PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field

Significant experience in preclinical pharmacology within biotech or pharmaceutical settings

Experience in choosing appropriate animal models

Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology

Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies

Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions

Strong statistical and data analysis skills

Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred