Scientist, RNA Biochemistry

Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered tRNA therapeutics. Our tRNAs target an underappreciated vulnerability of cancer: addiction to high levels of tRNA modifying enzymes. Cloverleaf’s approach to drugging tRNA modifying enzymes uses engineered “trojan horse” tRNAs to modulate translation in cancerous cells. The programmability, potency, and specificity of our tRNAs gives us the potential to dramatically improve cancer treatment.

We are seeking an experienced RNA Biochemist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.

Your responsibilities will range from designing and performing both low and high-throughput RNA screening assays, generation of RNA sequencing libraries, performing mechanistic studies in cells on lead candidate RNAs, and diving into new disease areas beyond oncology.

• PhD in Biochemistry, Molecular Biology, Genetics or related fields.
• Strong problem solving skills.
• Demonstrated ability to independently drive research projects to completion in academic or industrial settings.
• Experience with standard molecular biology techniques, including but not limited to, RNA/DNA extraction, PCR, RT-PCR, qPCR, western blotting, etc.
• Skilled in mammalian cell culture, passaging/seeding cells, etc.

• Competency generating libraries for RNA sequencing (such as mRNA-seq, CLIP-seq, etc.).
• Comfortable at analyzing NGS data analysis using conventional bioinformatics tools.
• Research experience in tRNA, RNA biology and/or RNA modifications field.
• Experience with design/development RNA therapeutics and lipid nanoparticles.
• Experience with mouse models of oncology.