gordian-biotechnology~8h ago

Senior Computational Biologist

United States·South San Franciscosenior

OtherComputational Biologist

0 views0 saves0 applied

Apply Now

Quick Summary

Overview

Large-scale transcriptomic data is at the heart of Gordian’s discovery platform. As a Senior Computational Biologist, you’ll analyze and help evolve our large-scale in vivo Perturb-seq workflows,

Technical Tools

OtherComputational Biologist

Large-scale transcriptomic data is at the heart of Gordian’s discovery platform. As a Senior Computational Biologist, you’ll analyze and help evolve our large-scale in vivo Perturb-seq workflows, partnering with disease experts to translate high-dimensional perturbational data into robust targeted hypotheses. You’ll bring creativity and technical depth to improving existing analyses while building new approaches - from multimodal reference integration to emerging foundation-model methods capable of revealing therapeutically-aligned cell states. By building a stronger analytical bridge between target nomination and validation, you’ll help improve our ability to distinguish compelling biological signals from noise and ultimately increase the impact of our screening platform across cardio-renal-metabolic disease programs.

Gordian Biotechnology is a therapeutics company whose mission is to cure age-related disease and wake up every morning more capable than the day before.

Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have mechanisms driven by complex, multi-cellular interactions with the aged environment. To address this problem, Gordian's Mosaic Screening pools interventions in living animal models of disease, producing datasets that more rapidly enable causal validation for hundreds of targets, in the living context of disease that can be mapped to human patients. This resource lets us make the most informed choices on what new ideas for treating complex disease, and move validated targets into drug development. (more info on our website, and in our preprint).

We are running this discovery engine in successive indication areas, currently focused on cardio-renal-metabolic diseases, to eventually map the effects of every druggable target across every relevant organ in vivo. Our ultimate mission is to develop drugs and run clinical trials, both internally and in collaboration with multiple partners. By pooling the data from each program, we seek to identify medicines with broad impact on the multimorbidity and decline caused by aging.

Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability.

Requirements

~1 min read

Prior work in cardio-renal-metabolic biology and relevant tissues (heart, kidney, adipose, liver), either directly or through close collaboration with disease experts.

Experience with in vivo Perturb-seq specifically, as opposed to in vitro or cell-line-only pooled screens.

Experience with spatial transcriptomics data (10X Xenium, Visium etc)

Gordian aims to provide everything you need to thrive. Beyond our community and science, you’ll have enough equity to be a true stakeholder in the company, competitive salary, full health/dental/vision/life insurance, 401k with match, onsite lunch paid for 3 days a week, basic onsite gym, whatever vacation you need to be at your peak, and access to world-class mentors and advisors to support your professional growth. Our building is in the heart of the biotech capital of South San Francisco.