Director, Portfolio Management

Business Introduction

GSK remains committed to achieving bold commercial ambitions for the future. By 2031, we aim to deliver £40 billion in annual sales, leveraging our existing strong performance momentum to significantly increase our positive impact on the health of billions of patients globally. Our Ahead Together strategy is centred on early intervention to prevent and alter the course of disease, thereby protecting people and supporting healthcare systems.
Our diverse portfolio consists of vaccines, specialty medicines, and general medicines.
Through continuous innovation and a dedicated focus on scientific and technical excellence, we strive to develop and launch new, groundbreaking treatments that address critical health challenges.



Position Summary

The role will be responsible for Decision Sciences and Portfolio Management in the Pharmaceutical portfolio (spanning preclinical Research and clinical Development, both in RI&I and beyond). This role will provide you the opportunity to support highly visible decisions at the senior leadership level, enhancing your enterprise-wide portfolio exposure, through objective analyses, portfolio context and a consistent approach across decision-making bodies to support pipeline investment decisions.

Specific responsibilities include:

• Guiding pipeline project teams across the R&D lifecycle (from preclinical to late-stage clinical development, and including business development) through strategic decisions and economic analyses (e.g. eliciting the probability of success, assessing the economics [ROI and NPV] of different project development options), facilitating team decision making and option evaluation, and bridging portfolio- and project-level considerations between senior leaders and teams

• Working with pipeline project teams to provide objective individual project assessments for R&D investment decisions at RI&I RU board, other Research Unit R&D governance and the Portfolio Investment Board (PIB)

• Providing specific recommendation(s) to investment body chair(s) on the opportunities being assessed, based on rigorous analyses of options, value-risk assessment, clear delineation of where risk is discharged, and how to optimise use of resources and capabilities

• Leading portfolio- or indication-level assessments to enable senior GSK leaders to make portfolio prioritisation and investment decisions, highlighting trade-offs based upon multiple factors (including scientific, clinical, commercial, strategic, operational, and financial)

• Bringing the external lens to portfolio and investment decisions, applying an equity analyst mindset to assess our assets as the market would by testing valuation assumptions, PTRS and peak sales against sell-side and competitor benchmarks.
• Supporting the biannual dynamic Portfolio Review (dPR) process for RI&I, ensuring refreshed pipeline project views and surfacing of new investment opportunities, and informing the RI&I portfolio prioritisation to optimise how functions deploy resources
• Collaborating with colleagues across the portfolio management team, the broader finance group, the Research Unit leaders, and partners in strategy, project management, operations, etc to recommend areas of short-term and longer-term focus from a disease area, indication, modality perspective and offer risk mitigation approaches to optimise the GSK portfolio overall including optimisation of resources

• Driving portfolio management effectiveness and efficiency by monitoring the external environment for insights on overall portfolio management, evaluating specific portfolio approaches in your areas (e.g. disease area or modality), and proposing use-cases to apply such innovations to portfolio decision making at GSK

• Enhancing the development of and deploying advanced analytics, including artificial intelligence and machine learning, to inform and shape decisions by teams and senior leaders

• Proven experience of pharmaceutical, healthcare or related industry experience
• Bachelor’s Degree in a related field

• Understanding of Commercial and/or R&D processes with experience in leading or supporting project teams in drug development preferred

• A track record of independent delivery on projects

• Demonstrate matrix management skills and clear ability to work effectively in a senior cross-functional team environment

• Demonstrate aptitude for managing multiple projects and priorities

• Apply skills to achieve expedited project delivery; including coordination and planning, fostering teamwork, and thinking strategically

• Demonstrate effective communication and negotiation skills for a wide variety of audiences, including senior management

• Demonstrate strong influencing skills and personal resilience, with sufficient depth in drug development to engage R&D leaders as a peer, constructively challenge development plans and shape decisions without formal authority

• Apply a well organised and methodical approach to problem-solving
• Set up processes and encourage others to create multiple options, strategies or contingency plans, where pros and cons are compared prior to deciding on the way forward

• High learning agility required to understand and facilitate technical, value and resourcing discussions to achieve the governance outcomes.
• PhD, MBA, other Advanced Degree

• Strong written and verbal communication skills to translate detailed scientific, technical and resource discussions into clear and concise presentations and recommendations.

• Adept at building trust and credibility with senior leaders and project teams to be sought after as a strategic thought partner and challenger.
• Cross-functional stakeholder management skills

• Demonstrated success in enabling and driving change

Work Location: This role is based from GSK HQ, London or Upper Providence, USA and offers a hybrid working model, combining on-site and remote work.

Closing Date for Applications: 20th October 2026

Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application OR your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a  Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive

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