Principal Scientist, Biologics Optimization

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

• Lead biologics optimization efforts across multiple therapeutic programs, translating target biology and desired mechanisms of action into rational protein engineering strategies. 
• Serve as a subject matter expert in function-driven optimization:  develop and champion novel development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Develop optimization strategies that integrate antibody sequence, structure, developability, and biological function to achieve program objectives. 
• Develop and champion novel display-based platform development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Lead/participate on project teams to advance discovery portfolio projects.  Act as a point of accountability for optimization engineering asks and manage project timelines independently.
• Partner with teams across TD/TA to define critical functional hypotheses and establish screening cascades that enable MoA-driven decision making. 
• Apply computational, AI/ML, and data-driven approaches to guide variant design, library construction, sequence prioritization, and hit selection. 
• Evaluate emerging technologies and develop innovative approaches to accelerate biologics optimization workflows and therapeutic discovery. 
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc.

• Education: A minimum of a MS Degree in in Molecular Biology, Biochemistry, Biotechnology, Biomedical Engineering, structural biology or related field is required. PhD is highly preferred.