Director, Oligo Team Lead

Boston · Boston · (boston)lead

OtherManagementDirectorDirector Oligo Team

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Overview

Manifold Bio builds AI models for protein therapeutic design, trained on proprietary experimental data generated at unprecedented scale.

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OtherManagementDirectorDirector Oligo Team

Responsibilities

~1 min read

→Build and lead a fit-for-purpose oligonucleotide therapeutic discovery team that includes both internal and outsourced expertise and capabilities, as needed.
→Lead 1-2 cross-functional drug discovery project teams, collaborating closely with protein engineers, in vitro biologists, bioconjugation scientists, and in vivo biologists to discover and progress shuttled oligo-based therapeutics.
→Work with company leadership and cross-functional experts to prioritize high-value therapeutic targets for tissue-targeted oligo therapeutics.
→Define best-in-class target product profiles for tissue-targeted therapeutic oligonucleotides. Define workplans and track progress to deliver on those target product profiles.
→Closely track advances in the field and provide strategic direction for continued development and expansion of Manifold’s shuttled oligo discovery efforts.
→Clearly communicate scientific progress and challenges to team members, leadership, and internal/external collaborators
→Establish and optimize innovative, efficient screening and production systems that leverage Manifold’s multiplexed in vivo screening capabilities.
→Serve as oligonucleotide therapeutic subject matter expert in discussions with potential partners, collaborators, and investors

Requirements

~1 min read

PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline)
Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs
Diverse experience with multiple oligonucleotide modalities (ASOs, siRNAs, aptamers, mRNA), different backbone chemistries/modifications
Knowledge of proven and emerging technologies for delivering oligo medicines to cellular targets (LNPs, passive or active targeting moieties, etc.)
Experience progressing oligonucleotide therapies from early discovery through IND-enabling preclinical activities / early clinical development
Demonstrated leadership of effective specialized and cross-functional scientific teams
Demonstrated ability to mentor junior scientists
Excellent written and verbal communication skills

Requirements

~1 min read

Experience designing and interpreting in vitro and in vivo systems assessing oligonucleotide efficacy and safety
Strong background in the engineering of optimized oligonucleotide conjugates, including linker discovery and bioconjugation optimization
Experience building and/or optimizing platforms for oligo design, synthesis, and screening
Understanding of DMPK, toxicology, developability, and CMC considerations specific to oligos
Track record of successful partnerships and external collaborations

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.