Profoundresearch15h ago

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Principal Investigator- Vaccines (Oceanside, CA)*

United States·Oceanside1099-Contractorlead

OtherInvestigator

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Quick Summary

Overview

About Profound Research Profound Research partners with community physicians to offer clinical trials as a therapeutic option for their patients. We handle all infrastructure, regulatory compliance,

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OtherInvestigator

About Profound Research

Profound Research partners with community physicians to offer clinical trials as a therapeutic option for their patients. We handle all infrastructure, regulatory compliance, and administrative operations so physicians can focus on patient care. Our model gives patients access to the newest therapies while maintaining the trusted patient-physician relationship.

Our Mission: Improving Lives by Providing Advanced Therapeutic Options

Our Vision: Creating the Absolute Best Patient-Physician Experience in Clinical Research

Our Values:

Compassion:

We prioritize the patient-physician relationship, ensuring every interaction is service-oriented and patient-centered.

Urgency:

We work hard and practice selflessness, acting swiftly and decisively to meet the needs of our patients, partners, and colleagues.

Solution Orientation:

We embrace challenges with a positive mindset, communicate directly, and identify and implement effective solutions with efficiency.

Excellence:

We insist on excellence, holding ourselves accountable and empowering each other to deliver best-in-class service while maintaining the highest ethical and scientific standards.

Why This Role Exists

At Profound Research, the Principal Investigator is the clinical cornerstone of everything we do at the site level. In this role, you’ll provide the medical expertise and oversight that makes safe, high-quality research possible – evaluating participants for eligibility, directing the conduct of the trial, and ensuring every decision reflects both scientific rigor and genuine care for the people who trust us with their participation. You’ll also serve as a direct extension of the trusted patient-physician relationship that sits at the heart of our model: participants aren’t just enrollees, they’re patients, and they deserve a physician who treats them that way. This is a role for a physician who wants to be genuinely present in the work – one whose judgment, accountability, and commitment to patients directly shape the integrity and success of the research.

What You’ll Do

• Serve as the physician of record for clinical trials at an assigned site, assuming overall responsibility for the safe and compliant conduct of each study

• Evaluate participants for enrollment eligibility and monitor their safety, well-being, and response to therapy throughout their trial participation

• Ensure every participant is treated with respect and experiences the kind of thoughtful, patient?centered care that reflects Profound’s values

• Provide clinical leadership and oversight to the on-site research team, delegating responsibilities appropriately and keeping staff informed and aligned

• Maintain a thorough working knowledge of each protocol – including visit schedules, endpoint criteria, and investigational product requirements – and ensure the trial is conducted accordingly

• Oversee informed consent, adverse event documentation, and all required safety reporting to the sponsor and IRB

• Ensure data accuracy and completeness across case report forms and source documents, and support the site’s readiness for monitoring visits and audits

• Collaborate effectively with sponsors, the IRB, and the Profound Research team throughout the life of the trial

Requirements

Essential Qualifications

• MD or DO with an active, unrestricted California medical license

• Prior experience conducting clinical research, with working knowledge of ICH/FDA/GCP guidelines and regulatory requirements • Proven ability to lead and collaborate with a multi-disciplinary clinical research team

• Strong communicator with patients, caregivers, clinical staff, and sponsor representatives

• High ethical standards, professional integrity, and a genuine passion for direct patient interaction

Preferred Qualifications

• Established relationships with community physicians or patient populations in the San Diego area

• Familiarity with CTMS platforms and electronic data capture systems

Physical Requirements & Work Environment

This role is performed on-site at a clinical or office facility and requires prolonged periods of sitting, standing, or walking throughout the work environment

Requires the ability to communicate clearly in verbal and written forms and to read and interpret detailed materials

Must be able to navigate a clinical facility, including areas with limited space, and transport supplies or work materials as needed

May be required to wear personal protective equipment (PPE) in accordance with facility protocols

Travel between company sites, meetings, or partner locations may be required

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of the role

Why Join Profound Research?

Meaningful Impact: Every role at Profound contributes to advancing medical knowledge and expanding therapeutic options for patients – the work we do here matters

Professional Growth: We invest in our people through comprehensive training, certification support, and ongoing education to help you grow in your role and your career

Leadership & Advancement: Profound is a place where initiative is recognized. We actively support internal growth and create pathways for people to take on greater responsibility over time

Collaborative Culture: You’ll work alongside a team of dedicated professionals who are passionate about clinical research and committed to doing it well

Full Benefits Package: Competitive compensation, health insurance, PTO, retirement plan, and professional development support

Diverse Clinical Exposure: Work across multiple therapeutic areas and study phases, building a breadth of experience that’s rare in a single organization (for Clinical / Patient-Facing roles)