Postdoctoral Fellow - Structural Biology and Drug Discovery

Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.

The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated postdoctoral fellow to join a multidisciplinary drug discovery program focused on a metabolic enzyme that plays a central role in cholesterol homeostasis and bile acid synthesis, with direct implications for metabolic disease and cardiometabolic risk.

As a successful candidate, you will:

• Lead efforts in recombinant protein expression and purification, and structure determination using X-ray crystallography to enable structure-guided ligand design.

• Collaborate at the interface of structural biology, chemical biology, and translational therapeutics, contributing to the development of first-in-class modulators targeting a clinically relevant metabolic pathway.

Your qualifications should include:

• Ph.D. in life sciences, biomedical sciences, or a related discipline is required.

• Prior experience in protein biochemistry and X-ray crystallography is essential.

• Experience in quantitative biophysical characterization of small-molecule binding studies such as SPR, ITC, and DSF and/or an interest in mechanism-driven drug discovery and fragment-based approaches is highly desirable.

• Proven track record of successful research projects and publications.

• Excellent analytical and problem-solving skills.

• Effective communication and collaboration abilities.

To learn more about our Comprehensive Benefits, please CLICK HERE.

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