Manager, Clinical Supply Chain - Planning

Overview: We are seeking an experienced individual for the role of Manager – Clinical Supply Chain, Planning. In this position, you will play a key role in developing and maintaining clinical supply plans across programs, supporting Alnylam’s growing pipeline and patient needs. Your focus will be on creating accurate, decision-ready demand and clinical finished good supply plans, ensuring alignment between protocol design, planning assumptions, and execution realities. You will partner closely with cross-functional teams including Clinical Operations, CMC, Global Planning, Regulatory Affairs, and Clinical Supply Chain Operations to ensure clinical supply strategies are well-defined and feasible. Overall, you will be responsible for translating complex inputs into clear planning outputs, identifying risks early, and ensuring planning assumptions enable successful trial execution. This position is hybrid and will be primarily located in the Alnylam Cambridge office. Responsibilities: * Build and maintain clinical supply forecasts by translating protocol assumptions (enrollment rates, dosing schedules, country footprint) into study-level demand and continuously updating forecasts as trials progress. * Develop integrated CFG supply plans that align forecasted demand with inventory strategy, ensuring adequate supply while minimizing overage, expiry risk, and waste across studies and programs. * Anticipate and quantify future supply risks (assumptions, scenarios, and constraints), and recommend mitigations and tradeoffs before they impact trial continuity. * Collaborate closely with Global Planning and CMC to relay demand forecasts into manufacturing, packaging, and release plans, ensuring alignment on lead times, capacity constraints, and material availability. * Engage with Program Development / Clinical Teams to validate and refine forecasting assumptions based on evolving study designs, enrollment dynamics, and protocol changes, ensuring forecasts reflect latest program reality. * Partner with Finance to connect demand forecasts to long range budget planning, and scenario modeling. Qualifications: * B.Sc. in a scientific field or Supply Chain Management or related field. * 4+ years of direct Clinical Supply Chain experience globally. * Knowledge of GMP / GxP / GCP and global regulatory requirements (FDA, EU, etc.). * Strong knowledge of clinical supply chain (packaging, labeling, inventory, global distribution) to enable accurate forecasting. * Understanding of clinical trial operations and drug development lifecycle. * Strong analytical and problem-solving skills with ability to track forecast accuracy and inventory performance. * Excellent communication and stakeholder management, with ability to clearly present forecasts, risks, and trade-offs. * Proven ability to operate in a fast-paced, matrixed environment while managing multiple studies with high accuracy and accountability. * Proficient knowledge of MS Office (Excel, PowerPoint, Visio, Project, etc.). #LI-KB1 #LI-Hybrid U.S. Pay Range $122,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.