Senior Director, Financial Planning & Analysis

City Therapeutics is biopharmaceutical company leading the future of RNA interference (RNAi)-based medicine. Co-founded by pioneering industry executives and backed by premier investors, we are rapidly expanding our sustainable product engine, which includes our ongoing Phase 1 clinical trial for CITY-FXI (targeting thromboembolic diseases) and multiple programs advancing toward the clinic.

The Senior Director of Financial Planning & Analysis (FP&A) will report to the Chief Financial Officer and lead the corporate FP&A function. You will own the strategic long-range planning (LRP), annual budgeting, and quarterly forecasting processes.  In addition, you will build and maintain long-range financial planning models to enable strategic analyses and decision making. This high-visibility role aligns finance with long range R&D operating plans, requiring a leader who can partner with the R&D organization to drive capital optimization and resource allocation.

• Lead the corporate annual investment plan and quarterly forecasting processes. Serve as a trusted business partner to scientific and operational leaders, helping translate functional and program operating plans into financial implications.  Compile and analyze financial plans and ensure those plans are linked to our underlying functional, program, and corporate goals. 
• Lead quarterly budget-to-actual variances analysis. Prepare management analyses detailing budget-to-actual variances and clear explanations of key cost drivers and present to leadership.
• Partner with the operational leadership to understand latest functional and program developments and ensure continued alignment with the corporate investment plan.
• Ensure functional and program visibility and ownership of Citys' investment plans. Provide visibility into investment plans, performance versus that plan, as well as levers to ensure financial targets are met. Provide ad-hoc financial and/or business case analyses, as needed.
• Proactively recommend actions to ensure actual spending continues to align with financial targets.
• Drive the longer-term migration from an Excel-driven modeling tool to a dedicated corporate forecasting platform integrated with the corporate ERP.

• Develop City's long-range financial model by working with leadership to determine long-term capital needs under various pipeline progression scenarios. Quantify investments scenarios to proactively determine capital needs, cash runway, identify and quantify value inflections points and opportunities to gate spend, and assess future financing windows.  Present findings to senior management.
• Deliver cash-burn analysis and multi-year liquidity scenarios to advise executive leadership on capital requirements and fundraising strategies.
• Partner with leadership team to build/maintain a scenario-based corporate valuation model.
• Partner with Business Development colleagues by providing financial modeling, valuation, term sheet negotiation, and contracting support, as needed.
• Track and analyze Wall Street analyst models to evaluate how internal forecasts align with external market expectations and support investor relations.
• Prepare financial performance summaries, KPIs, and dashboard visualizations for presentation to senior leaders in the organization.
• Assist in preparing clear and concise presentations for the Executive Team and the Board of Directors.

• Education: Bachelor’s degree in Finance, Accounting, Economics, or a quantitative field. MBA is preferred.
• Experience: 10+ years of progressive finance experience, with at least 3 years heading FP&A within a biopharmaceutical or biotechnology organization.
• Industry Acumen: Mandatory background in clinical-stage biotech, featuring deep technical familiarity with CRO/CMO contract structures, clinical accruals, and R&D pipelines.
• IPO / Public Company Exposure: Experience navigating a company through an IPO and/or operating within a recently publicly listed life sciences environment.
• Technical Skills: Expert-level financial modeling skills; proven ability or project management experience transitioning an FP&A department from manual spreadsheets to an automated forecasting platform.

• Attributes: Exceptional executive presence with the ability to clearly explain complex financial outcomes to non-financial scientific leaders. High attention to detail while managing multiple projects.  Ability to work independently in a fast-paced environment.

At City, we believe that science and culture thrive together, and that happens best in person. Our working model is clear: we work onsite at our Kendall Square offices five days per week.

This choice reflects our belief that great science and cultures run on connection, fairness, and growth.

• Connection: Face time matters. Building an enduring biotech company is about people, science, and strategy. Working side by side sharpens ideas, accelerates feedback, and fuels innovation for patients.
• Fairness: One model for all. Every voice counts, and fairness depends on shared experience. We hold ourselves to one standard across all levels and functions.
• Growth: Learning moves faster in person. Growth comes from conversation, observation, and mentorship. We believe in developing talent, and that happens best when we are together.

We also know that life is not always predictable. When individual needs arise, we are flexible and supportive and work together to balance home life with life at City.

We believe diverse teams drive better science. We welcome applicants from all backgrounds and experiences who share our mission to bring transformative RNAi medicines to patients.

City Therapeutics is an Equal Opportunity and Affirmative Action employer. All qualified applicants will receive consideration without regard to race, color, religion, national origin, gender, gender identity or expression, sexual orientation, age, disability, veteran status, or any other characteristic protected by law.