Principal Scientist, Protein Production & Engineering

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.

Disc Medicine is seeking a detailed-oriented and experienced protein biochemist who will join our Innovation team as a Principal Scientist/Associate Director reporting to our Senior Director, Protein production and engineering. This individual will lead the discovery, design, production and/or characterization of biologics at various discovery and development stages, effectively communicate project updates and contribute to the company portfolio with meaningful opportunities for professional development.

• →Provide scientific leadership in the planning, execution, and data interpretation across multiple biologics discovery programs.
• →Lead protein engineering strategies for various antigens and biologics (antibodies and multi-specifics) using experimental, computational and structural biology tools
• →Design and oversee the protein production and detailed characterization processes to support projects across the Innovation portfolio
• →Drive early-stage developability assessment workflows of biologics
• →Support mechanisms of action studies through assay development
• →Support the selection of lead molecules to advance pipeline programs.
• →Critically evaluate scientific literature, synthesize novel hypotheses and design and integrate rigorous experimental strategies to test them.
• →Communicate project progress and key findings effectively in cross-functional meetings, ensuring alignment with timelines in a fast-paced, dynamic environment.
• →Foster a collaborative and accountable team culture, with a strong emphasis on scientific excellence and continuous improvement.

• Ph.D. in Biochemistry, Structural Biology, Protein engineering, or a related field.
• 10 -12 years of related work experience with at least 5 years of experience working within the biotechnology or pharmaceutical research industry.
• Extensive experience in biologics discovery and protein sciences, including fusion proteins and multi-specific antibodies
• Deep expertise in the characterization of protein structure and function (affinity, stability, developability, etc.)
• Strong background in the use of computational and structural biology tools for protein design is a plus.
• Tech transfer knowledge from Research to Development teams is a plus
• Demonstrated ability to think critically and independently, propose innovative scientific approaches, and apply strong analytical and problem-solving skills to complex biological questions.
• Experience working with contract research organizations (CROs) is preferred.
• Outstanding communication skills—both written and verbal—with the ability to thrive within a collaborative work environment.