Empiricotx4mo ago

Senior Scientist - CMC

United States·MadisonFull-timesenior

OtherScientist

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Empirico,

Technical Tools

OtherScientist

Empirico, a clinical-stage biotechnology company that combines unmatched expertise in human genetics-driven target discovery with world-class capabilities in siRNA medicines is seeking a chemist with an interest in solid-phase oligonucleotide synthesis and analytics. This is an excellent opportunity for a highly motivated, creative scientist to be a vital member of our team.

You will be responsible for supporting the synthesis, purification, and characterization of oligonucleotides and their conjugates, and optimizing methodologies to support the development of siRNA medicines. The ideal candidate will have experience in organic and analytical chemistry and both upstream and downstream oligonucleotide manufacturing processes. A key focus of this role will be developing scalable processes suitable for technology transfer to CDMOs. You will be expected to –

Perform solid-phase synthesis, purification, and characterization of oligonucleotides

Develop and optimize scalable upstream (synthesis) and downstream (purification, formulation) manufacturing processes

Support process development activities to enable successful technology transfer to CDMOs

Analyze, interpret, and clearly communicate synthetic and analytical data

Present findings to senior staff and cross-functional teams

Troubleshoot and refine synthesis and purification protocols

Manage multiple projects simultaneously in a fast paced environment

Support GLP related activities and IND-enabling process development efforts

This position requires a BS in Chemistry with at least 12 years of relevant industry experience, or an MS in Organic Chemistry, Biochemistry, or Chemical Engineering with at least 7 years of relevant experience, or a PhD with at least 3 years of relevant experience.

Industry experience in solid-phase oligonucleotide synthesis is preferred, as well as familiarity with both upstream and downstream oligonucleotide manufacturing processes

Minimum 1 year of experience working in a cGMP environment with demonstrated understanding of cGMP principles

Hands-on proficiency with analytical instrumentation such as NMR, LC-MS, and RP-HPLC

Demonstrated ability in analytical and purification method development using RPIP-HPLC, AEX-HPLC, UV, MALDI, and HRMS

Background in process development and technology transfer to CDMOs, including development of scalable purification and formulation methodologies

Working knowledge of tangential flow filtration (TFF) method development

Experience supporting GLP studies and familiarity with regulatory expectations for IND-enabling work

Experience with lyophilization and aseptic fill/finish operations

Applicants must have authorization to work in the U.S.