Head of Clinical Sciences

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

• →Lead the global clinical science strategy, endpoint selection, end-to-end protocol development, and associated amendment(s) across the full trial lifecycle, ensuring high level of quality and operational delivery. 
• →Spearhead the end-to-end clinical data review process, synthesizing complex data to deliver evidence-based strategic recommendations to executive leadership.
• →Accountable for safety monitoring and risk management strategies, interpreting safety/efficacy data to guide critical decisions.
• →Author and review key clinical and regulatory documents. 
• →Facilitate cross-functional collaboration to transition research stage assets to clinical development and integrate translational insights to influence broader program strategy.
• →Represent the organization in health authority interactions and lead the scientific rationale for regulatory responses. 
• →Build and maintain strategic relationships with external partners (e.g., Key Opinion Leaders, Principal Investigators, and CROs) to validate program direction and support investor relations activities.
• →Define and implement scalable clinical science best practices, SOPs, and governance frameworks to ensure speed, consistency, and inspection readiness. 
• →Define the unifying scientific messaging across internal and external stakeholders, supporting publication strategies and commercial positioning.
• →Collaborate with internal AI/ML teams to identify and implement technology-driven solutions to enhance scientific literature analysis, clinical data interpretation, and overall operational efficiency. 
• →Requires some travel.

Essential:

• Education: Advanced degree (MD, PhD, PharmD).
• Experience: 15+ years in the pharmaceutical/biotech industry, with a proven track record in small to mid-sized startup environments. Deep expertise in oncology or inflammation. 
• Track record: Proven success in leading programs from IND through late stage development. Experience leading successful regulatory filings. 
• Scientific Rigor: Strategic ability to interpret complex, ambiguous datasets to drive corporate strategy and mitigate development risks.
• Leadership Effectiveness: Demonstrated success in a fast-paced matrixed environment. Strong interpersonal skills with the ability to influence without authority and resolve conflicts across global functions. 

Preferred:

• The Builder: Comfort in a fast-paced, evolving start up with experience building foundational capabilities from scratch. 
• The Diplomat: A master of cross-functional influence who can build consensus and navigate complex governance with high emotional intelligence. 
• The Innovator: Knowledge of industry trends and technologies to drive competitive advantage, leveraging automation or digital tools to simplify workflows and accelerate the path to patients. 

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. 

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