Associate Scientist, HTS & NGS

Cambridge · CambridgeFull-timemid

OtherAssociateScientist

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Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform.

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OtherAssociateScientist

Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts.

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

Position Summary: Korro Bio is seeking a highly motivated Associate Scientist to join our HTS-NGS operations team and work with an enthusiastic team of highly skilled scientists. The ideal candidate for this lab-based position is committed to delivering high quality results in a timely manner. This is an exciting opportunity to be part of a collaborative team and contribute to the development of next-generation RNA editing technology and therapeutics in a fast-paced biotech company.

Independently design and execute high-throughput cell-based assays to support oligonucleotide platform and portfolio projects

Perform amplicon-seq library preparation and quality control, operate and maintain NGS platforms and associated laboratory equipment

Troubleshoot HTS assays, library preparation, and sequencing workflows as needed

Analyze and present HTS-NGS data based on results in a team setting; collaborate with cross-functional teams to support lead discovery

Support NGS scientists in operational tasks, including inventory management, assay development, and operations improvement

Accurately document project and sample information, protocols, and experimental details through an Electronic Lab Notebook (ELN)

MS with 3+ years or BS with 5+ years of experience in molecular biology, cell biology, or related field

1+ years of hands-on experience with high-throughput assays and automated workflows

Experience with cell culture techniques, including plating and transfection in 96/384-well formats

Experience with NGS assays: amplicon-seq and RNA-seq, including primer design, library preparation, quantification, and data quality control

Demonstrated expertise in molecular biology techniques: RNA/DNA isolation, transfection, PCR/qPCR, gel electrophoresis

Familiarity with liquid handling systems (e.g., Viaflo96/384, HiRes/Certus Flex, Tempest) is highly preferred

Hands-on experience with next-generation sequencing platforms and equipment including Illumina (MiSeq i100), Qubit, Tape Station, and Fragment Analyzer is highly preferred

Experience with LIMS systems (Benchling) and project management tools (Jira/Confluence)

Strong troubleshooting skills and ability to suggest and implement new solutions independently

Excellent written and verbal communication skills with attention to detail

Ability to thrive in a fast-paced and evolving environment