AI in Residence

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

AI in Residence is a highly selective role at the intersection of frontier machine learning and drug discovery. Designed as an industry alternative to a traditional postdoctoral position, the program is for exceptional researchers and engineers who want to apply advanced AI to real biomedical problems end to end, from data to deployed systems.

Residents join a small cohort working on high-impact AI efforts across Xaira. You’ll collaborate closely with AI scientists, research engineers, and drug discovery teams to design, build, and ship machine learning capabilities that directly influence therapeutic programs. This is hands-on, system-level work with real scientific consequence.

We’re looking for candidates with technical depth, intellectual independence, strong research judgment, and evidence of delivering high-quality work—whether through publications, open-source, or production systems.

• →Develop and advance ML models for biological, preclinical, and translational datasets (e.g., multimodal omics, imaging, text, assay data)
• →Design and implement scalable pipelines for data curation, training, evaluation, and inference integrated into discovery workflows
• →Own projects end-to-end: problem framing → prototyping → validation → deployment
• →Evaluate robustness and reliability (generalization, uncertainty, failure modes), plus interpretability where it supports scientific decision-making
• →Contribute technical leadership by proposing new directions, shaping platform capabilities, and raising engineering/research standards through collaboration
  
  

Examples include (not limited to):

• Foundation / representation models over multimodal biological and translational data
• Methods for small, biased, noisy datasets; distribution shift; and uncertainty estimation
• ML systems for experimental prioritization, assay interpretation, or translational signal discovery
• Evaluation frameworks and benchmarks tailored to discovery decision-making
• Tooling that makes models usable by scientists (interfaces, automation, monitoring)
  
  

• You ship one or more models or pipelines that are used in real discovery workflows
• Your work improves decision quality (e.g., better prioritization, faster iteration, clearer uncertainty)
• You raise the bar on evaluation rigor and reproducibility (strong baselines, error analysis, reliable metrics)
• You leave behind maintainable systems (tests, documentation, monitoring) that others can build on
  
  

• Strong research judgment: choosing the right problems and knowing what “good evidence” looks like
• Rigor: careful experimental design, ablations, error analysis, and honest reporting
• Systems thinking: reliability, scalability, and maintainability—not just prototypes
  Clear communication: writing, documentation, and sharing decisions/assumptions
• Collaborative execution with scientific and engineering partners
  
  

We encourage applications from candidates who meet most of the following:

• Recent MS or PhD graduates (or equivalent research experience) in ML/AI, computational biology, biomedical engineering, or related fields
• Evidence of research excellence through high-quality publications or artifacts. Top venues (e.g., NeurIPS, ICML, ICLR, CVPR, ACL; Nature Methods, Cell Systems) are a plus, but strong preprints, open-source contributions, or shipped systems with demonstrated impact are equally compelling
• Demonstrated ability to lead substantial technical work with originality—new modeling ideas, rigorous experiments, or production-grade systems adopted by others
• Motivation to translate rigorous research into reliable, deployable AI systems that support therapeutic discovery
  
  

Please include a brief cover letter describing your interest in this role, why you’re excited about this area, and what you hope to gain from the experience.