Associate Scientist

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

• High throughput protein expression, purification and characterization from multiple systems including cell free systems and mammalian is the primary responsibility.
• Drive team throughput and data quality by developing novel strategies for parallel protein processing. Key responsibilities include optimizing expression and purification workflows and conducting quality control and functional assays for proteins used in therapeutic development and in silico design.
• Excellent record keeping and organization is a must
• The experience and flexibility to work on upstream medium scale expression and downstream purification is a plus.
• Perform analytical characterization of purified proteins using HPLC, CE-SDS, and icIEF to ensure high-quality candidates for therapeutic development.

• B.S. (6+ years) or M.S. (6+ years) in a relevant scientific discipline; industrial experience preferred. (PhD (2+ years)
• Proven expertise in high-throughput (HTP) protein production, with a specific focus on cell-free protein expression (CFPE) and/or mammalian transient expression systems.
• Understanding of the biophysics of protein-protein interactions, protein chemistry, experience in the molecular biology and biophysical techniques essential for protein work is required.
• Demonstrated hands-on experience with high-throughput (96/384-well) expression and purification workflows.
• Proven track record of independent project management and cross-functional collaboration.
• Dedicated to inclusive leadership and maintaining a respectful, diverse team environment.