USD 120000-165000/yr

Talent & People Operations Lead

United StatesEmeryville · Hybrid (2Hybridlead
OtherPeople OperationsPeople Operations LeadHuman Resources
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Quick Summary

Overview

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville,

Technical Tools
OtherPeople OperationsPeople Operations LeadHuman Resources

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.

We’re looking for a strategic and hands-on Talent & People Operations Lead to own the full recruiting lifecycle and strengthen our people operations as part of the Operations team. You will play a critical role in building Profluent’s team and culture - ensuring we attract, hire, and retain top talent while creating an employee experience that enables people to thrive.

This role will begin with a strong focus on talent acquisition alongside core people operations, with the opportunity to expand into broader ownership across people operations and HR. This is an excellent opportunity to directly shape our team and culture during a pivotal stage of growth.

Responsibilities

~1 min read
  • Lead full-cycle recruiting across technical and G&A functions, from sourcing to closing
  • Define, lead and execute strategy to ensure we meet the approved hiring plan
  • Partner with hiring managers and leadership to define roles, set hiring strategies, and ensure efficient processes
  • Build and maintain a strong candidate pipeline through sourcing, networking, and outreach
  • Develop and strengthen Profluent’s employer brand to attract top talent; ensuring postings, candidate experience, and external presence reflect our mission and culture
  • Own and improve HR processes, including onboarding, benefits, compliance, and offboarding
  • Drive initiatives that enhance employee experience such as team events, onboarding programs, and recognition efforts
  • Lead performance management and employee engagement programs
  • Collaborate across operations, scientific, and leadership teams to anticipate and address people-related needs
  • Act as the primary point of contact for all HR and Ops questions, and effectively triage and escalate as appropriate

Requirements

~1 min read
  • At least 5 years of experience in dedicated recruiting, with additional experience in people operations, ideally in a high-growth environment
  • Experience as a full stack recruiter
  • Experience sourcing technical talent
  • Understanding of or a desire to learn HR fundamentals, including compliance and employee relations
  • Excellent interpersonal, project management, and communication skills
  • Ability to thrive in ambiguity, build structure, and drive outcomes independently
  • Ability to maintain the highest standards of confidentiality when handling sensitive business information
  • Experience in biotech, life sciences, or AI/tech startups 
  • 2 years+ of experience at an early stage (Series B or earlier) company
  • Familiarity with ATS, HRIS, and other people systems (e.g., Greenhouse, Rippling)
  • Exposure to compensation planning and organizational development
  • HR experience outside of recruiting 

What We Offer

~1 min read
High-growth opportunity with meaningful impact on the future of protein design
Competitive compensation package with equity participation
401(k) with a strong employer match
Comprehensive benefits including health/dental/vision insurance
Generous PTO policy and commitment to work-life balance
Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Requirements

~1 min read

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

Hiring Salary Range
$120,000$165,000 USD

Listing Details

First seen
April 3, 2026
Last seen
April 27, 2026

Posting Health

Days active
23
Repost count
0
Trust Level
44%
Scored at
April 27, 2026

Signal breakdown

freshnesssource trustcontent trustemployer trust
Profluent
Profluent
greenhouse

Profluent is an AI-first protein design company focused on developing generative models to create novel proteins for transformative applications in biomedicine.

Employees
125
Founded
2022
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ProfluentTalent & People Operations LeadUSD 120000-165000