Sales Director, HDV Business Unit

Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously.

The Sales Director, HDV Business Unit will lead a highly specialized field team of Regional Account Managers (RAMs) tasked with preparing the U.S. market for the anticipated launch of Brelovitug for Hepatitis Delta Virus (HDV), pending regulatory approval. This role is responsible for advancing disease awareness, supporting account readiness, and helping to establish the foundation for appropriate patient identification and management in a market with profound unmet need.

HDV represents the most severe form of viral hepatitis, requiring Hepatitis B co-infection for replication and spread. Despite an estimated U.S. prevalence of ~40,000 patients and ~15,000 who are diagnosed, insured, and under care, there are currently no approved therapies in the U.S., underscoring the urgency and importance of this role.

This leader must excel at operating in ambiguity—defining strategy, building structure, and driving execution in a market that is still being shaped in real time.

• Build and lead the HDV team of 6 Regional Account Managers across key U.S. geographies
• Develop and execute a pre-launch market development strategy focused on HDV disease awareness and diagnosis expansion
• Identify and prioritize high-value accounts within key HDV geographies
• Translate evolving epidemiology, market insights, and competitive dynamics into actionable, compliant field strategies
• Create clarity from ambiguity by setting direction, establishing priorities, and adapting strategy as new information emerges

• Drive awareness of HDV as a severe, underdiagnosed condition requiring urgent intervention
• Expand understanding of the relationship between HDV and Hepatitis B (HBsAg dependency)
• Partner with KOLs and key institutions to support HDV screening, diagnosis, and referral pathways
• Support initiatives to improve patient identification within the estimated ~40,000 patients under care

• Ensure strategic engagement across key stakeholders and health systems
• Establish account plans focused on screening protocols, care pathways, and disease management readiness
• Collaborate cross-functionally with Medical Affairs, Market Access, and Marketing to ensure aligned execution
• Support accounts in enhancing (or operationalizing) HDV identification and management in the absence of established standards

• Recruit, develop, and coach a high-impact team of RAMs
• Set clear expectations aligned with pre-launch, non-promotional objectives
• Foster a culture of accountability, agility, and mission-driven execution
• Coach the team to operate effectively without fixed playbooks—encouraging problem-solving, adaptability, and proactive compliant decision-making
• Lead through influence in a complex, cross-functional environment

• Serve as the field leadership voice in launch planning
• Partner closely with:
  • Medical Affairs on scientific exchange and KOL engagement (as appropriate and compliant)
  • Market Access on payer readiness and coverage considerations
  • Commercial leadership on launch readiness and execution
• Align stakeholders around evolving strategies, even when data, timelines, or market conditions are still emerging

• Bachelor’s degree required; MBA or advanced degree preferred
• 7+ years of pharmaceutical/biotech experience, including field leadership
• Proven success leading account-based or specialty field teams through ambiguity
• Experience in rare disease, hepatology, infectious disease, or specialty launches
• Demonstrated ability to build strategy in pre-launch environments
• Strong understanding of U.S. healthcare systems, IDNs, and academic centers
• Experience with Hepatitis B, liver disease, or transplant networks preferred
• Launch experience in a market with low awareness/high unmet need
• Strong KOL engagement and scientific fluence
• Thrives in a fast-paced, dynamic, and collaborative environment
• Able to travel frequently, up to 70% overnight travel and has a valid drivers’ license

• Strategic thinker with strong execution discipline
• Comfort leading through ambiguity—able to make decisions with incomplete information and adjust rapidly
• Ability to build structure and momentum from the ground up
• Exceptional leadership and team development skills
• High emotional intelligence and stakeholder influence
• Mission-driven mindset aligned to addressing critical unmet need
• Ability to understand and effectively communicate scientific information within role and scope
• Foster a culture of innovation, accountability, and entrepreneurial thinking

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